Several TMAU2 positive tested people reported that their body odor symptoms increased strongly in stress related situations.
As we now have included the noradrenaline and adrenaline degradation path, the metabolism map shows a high impact in both pathways.
If a enzyme defect around the BHMT enzyme is assumed, the result would be that the intestinal tract runs very fast out of SAM (S-adenosyl-methionine).
Low SAM levels would of course be further drained by the release of noradrenalin and adrenaline.
In both degradation pathes the COMT enzyme is responsible for the further drain of SAM.
RNA expression of the COMT shows clearly that COMT is not only present in the brain, instead in the intestinal tract, liver, etc. as well.
The COMT enzyme was once the major target of schizophrenia research.
Today it seems that the body odor diseases are strongly related to enzymes which cause schizophrenia and depression.
The main difference is that those enzymes are in the body odor cases locally inhibited within the intestinal tract area.
Nevertheless is the relation so strong that it might be appropriate to name the body odor disease impacts as 'schizophrenia of the intestinal tract'.