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Candida pathogenesis in Bromhidrosis

Our observation was that bromhidrosis patients reported slight elevated candida sp. levels in combination mit reduced enterococcus sp. in stool analysis results.

The current metabolism impact for bromhidrosis seems to be sourced in a deficient acetate or propionate degrading enzyme which is part of the major ethanol degradation.

The biosynthesis of ethanol is mostly based on candida sp., so we investigated into the pathogenesis of candida.

The following pictures show the resulting disease model.

In the case of an deficiency in the ethanol degradation pathway, the immune system shows a weakness regarding the candida sp., which shifts the microbiome towards increased candida occurence and activity.

This would lead to small intestinal fungal overgrowth (SIFO) symptoms 

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Comments

  1. NKSeptember 7, 2017 at 3:29 AM

    Is this reversible condition? as in , enzyme supplements can reverse bromhidrosis ? or any other deductible course of treatment/management ?

    ReplyDelete
  2. aliceSeptember 7, 2017 at 3:49 AM

    Antifungals like nystatin show their effect after 3-4 weeks. Be aware, that it only lowers the body odor to a certain degree and mostly the propionate compound and not the other compounds necessarily.
    It seems to apply to one type of Bromhidrosis patients with elevated TSH and not necessarily to other bromhidrosis types.
    Other types with elevated PTH e.g. seem to react much better on calcium reduction and vitamine D reduction.
    Btw: there are fecal analysis tests available which show candida sp. distribution and elevated results in above cases. measure first if possible even if e.g. nystatin is a well known drug with only low side effects.


    ReplyDelete
    Replies
    1. NKSeptember 7, 2017 at 5:09 AM

      This comment has been removed by the author.

      Delete
    2. aliceSeptember 8, 2017 at 10:36 AM

      Do you wanna send me more details per mail?
      awonderland6( at )googlemail.com

      Delete
  3. Femi Louis OgumahAugust 7, 2018 at 2:48 PM

    I've been following on series of your articles I just want to let you know that it has been so educating, with resourceful guide that has change a lot in the life of many. In-fact the insights I believe is defining tomorrow. Thank you for this great info.
    Keep up with the nice work.
    Regards

    ReplyDelete

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