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Histamine has a strong impact on tight junction regulation of intestinal cells

In previous posts was mentioned that the fecal body odor seems to be related histamine degradation deficiency.

What impact does that have?

It looks like histamine concentrations are highly important for the tight junction regulation of intestinal cells.

The tight junctions are important for the direct paracellular transport of electrolytes into the blood without transition through the intestinal cell metabolism.

Increased open tight junctions will further lead to an increased surface area of the intestinal cells and are as a result a strong regulator of passing amines and their level of being processed.


One of the regulation relevant receptor for the tight junctions is the H1 receptor.

When mast cells e.g. get active they release histamine to open those tight junctions.

So a relation to food allergies as a initial trigger seems to be a possible factor with an upfollowing malregulation of the histamine concentrations.

The malregulation would be based on the increased histamine levels passing through the too wide opened tight junctions and the downregulation of HNMT enzyme by higher acetate electrolytes.

If we look at the indole chemical it is important to know that recent research has shown that indole acts as an tight junction closing regulator.
This makes sense since the area were the intestinal cells have to down regulate the amount of passing chemicals is variable and dependant of the daily fermentation levels of the digested foods.
So the body can adapt the intestinal cells with tight junction regulation very good.

As an impact on body odor sufferers can the negative overregulation of tight junction proteins bein named.

All major body odor types seems to have that symptom in common.

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  1. Nero CaseificioJuly 18, 2019 at 3:40 PM

    Hi, I suffer from both Mast cell activation syndrome and bromhidrosis, I find this very intresting, actually It's the only one research I've found that connect these problems. I hope you will find out more :)

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