Skip to main content

The strong sweaty smell of 'apocrine' bromhidrosis seems caused by an enzyme defect in the propionate and butyrate degrading enzymes

The classical view of dermatology regarding the cause of a strong sweaty underarm odor is that a defect function of apocrine sweat glands is present.

As a result dermatologists consider chirurgical removal of the apocrine sweat glands as the only way to treat such an odor.

We made a chemical analysis of clothes of patients using GC-MS. On the outer limit of the GC was a peak in butyric acid shown.

Butyric acid seem to build up in the clothes of patients over time.

When we investigated into the human metabolism regarding butyric acid we found immediately the butyrate degrading enzyme 

This enzyme is mostly present in the liver, degrading butyrates (butyric acid salts) which are taken up as main energy source for the large intestinal tract sourced by the bacterial fermentation processes within the gut.

The same pattern applies to propionates (propionic acid salts) which are degradated by the EC enzyme.

As a result it is very likely that a strong 'sweaty' smell which does not disappear after showering is caused by a defect in such enzymes.


  1. Hi, how can these enzymes' defect can be remedied?


Post a Comment

Popular posts from this blog

Candida pathogenesis in Bromhidrosis

Our observation was that bromhidrosis patients reported slight elevated candida sp. levels in combination mit reduced enterococcus sp. in stool analysis results.
The current metabolism impact for bromhidrosis seems to be sourced in a deficient acetate or propionate degrading enzyme which is part of the major ethanol degradation.
The biosynthesis of ethanol is mostly based on candida sp., so we investigated into the pathogenesis of candida.
The following pictures show the resulting disease model.
In the case of an deficiency in the ethanol degradation pathway, the immune system shows a weakness regarding the candida sp., which shifts the microbiome towards increased candida occurence and activity.
This would lead to small intestinal fungal overgrowth (SIFO) symptoms