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Homeless people, sweaty body odor and alcohol

Everyone once in their lifetime encountered a homeless person which presented itself with a strong sweat like smell.

Most people do relate this to poor hygiene, even if that smelly person does not show outer signs of poor hygiene.

For some homeless people poor hygiene might be a reason, nevertheless from a metabolic point of view there might be an alternative major reason: higher alcohol consumption in combination with lower food intake

If we look at the ethanol degrading pathway, we realize that it compromises the EC in an overload situation pretty similar to the case when people having a primary enzyme deficiency in this enzyme.

As a result it might be that the Clochard Smell Syndrom is caused by an metabolic impact on the EC enzyme and the related butyrate and propionate enzymes.


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Candida pathogenesis in Bromhidrosis

Our observation was that bromhidrosis patients reported slight elevated candida sp. levels in combination mit reduced enterococcus sp. in stool analysis results.
The current metabolism impact for bromhidrosis seems to be sourced in a deficient acetate or propionate degrading enzyme which is part of the major ethanol degradation.
The biosynthesis of ethanol is mostly based on candida sp., so we investigated into the pathogenesis of candida.
The following pictures show the resulting disease model.
In the case of an deficiency in the ethanol degradation pathway, the immune system shows a weakness regarding the candida sp., which shifts the microbiome towards increased candida occurence and activity.
This would lead to small intestinal fungal overgrowth (SIFO) symptoms