Body Odor Research Blog

In our explorative case we were further able to improve the diet protocol as well as finding a new drug/supplement  composition. We are taking advantage of following over the counter drugs/supplements: - Nystatin - Nigella sativa (black cumin) capsules - H1 receptor antagonists (loratadin) - medicinal clay The diet protocol was taken from: https://drive.google.com/folderview?id=19hmatFJPil1svc9DRyuRn3S9rUF7yqH_ Dosages (daily) applied were like the following: nystatin: 6x pills (3x at morning, 3x at evening) nigella sativa: >10000mg (5x 400mg capsules before every meal, 5 meals per day) loratadin: 50mg - 100mg daily medicinal clay: 6x 6g (luvos healing earth)

Glutamine and its counterpart glutamate seems to increase the butyrate production in the intestinal tract. Butyrates show a biting or pungeant, light sweat like smell. This strengthens the view that the tight junction sealing is dominated by metabolite pathways that present in one or the other way highly smelling chemical compounds the body is forced to absorb to counter regulate its deregulated energy metabolism in the intestinal tract .

Metabolic flux alignments showed first indications that the ammonia production might be reduced in some bromhidrosis cases. This might leed to fast glutamine drainage in intestinal cells. As a result glutamine supplementation might help ameliorating the low levels of glutamine and the reduced antioxidative effects in the cells. A test with CACO2 test cells from the collegues from the alcoholism research showed promising results with glutamine as well. A further supportive candidate is quercetine which is an antioxidant and a propsed inhibitor of the protein kinase which is related to the cAMP signaling. The cAMP signaling might be overactive in the same bromhidrosis cases. The cAMP signaling is calcium and Vitamine D dependent, in the form that calcium and Vitamine D do further overactivate the cAMP signaling, which might have negative impacts.

Collegues from the research field of alcoholism had a first succes in lowering the negative tight junction effect of acetaldehyde which seems to be one of the major malregulation factors in Bromhidrosis with TSH+. They used NAC successfully  in CaCo-2 cell tests. NAC is widely available as Supplement.

Based on the data of the USDA Food Composition Database we extrapolated four groups of foods. The respective lists can be found here: https://drive.google.com/folderview?id=0B9gtX6As3TJGa25zX1ZvNmZROUU

Our observation was that bromhidrosis patients reported slight elevated candida sp. levels in combination mit reduced enterococcus sp. in stool analysis results. The current metabolism impact for bromhidrosis seems to be sourced in a deficient acetate or propionate degrading enzyme which is part of the major ethanol degradation. The biosynthesis of ethanol is mostly based on candida sp., so we investigated into the pathogenesis of candida. The following pictures show the resulting disease model. In the case of an deficiency in the ethanol degradation pathway, the immune system shows a weakness regarding the candida sp., which shifts the microbiome towards increased candida occurence and activity. This would lead to small intestinal fungal overgrowth (SIFO) symptoms 

Today we release a new curated metabolism map regarding body odor diseases. The new map alignes around the main inhibited enzymes by body odor diseases. Beside of that a first receptor linkage has been included. The map further shows now measured chemical compounds in unnormal ranges of tmau2 and bromhidrosis with elevated TSH. Obviously in the tmau2 case the measurements align pretty good with the assumption that the intestinal tract metabolism runs out of SAM (S-adenosyl-methionine) by defects in the homocysteine to methionine conversion. https://drive.google.com/file/d/0B9gtX6As3TJGTDVfNDRfek1WLTA/view?usp=drivesdk

In an explorative case with strong sweaty body odor, normally associated with 'apocrine' bromhidrosis, the odor emission reduces drastically after two weeks of large doses of loratadin (>50mg daily) During that period a diet was in place: - exlusion of high histidine foods - exclusion of sugar holding foods - meals did contain only proteins or carbohydrates but no mixture of both During that period following supplements were taken: - DAO - Vitamine C (1000mg) - Medicinal clay especially for histamine intolerance