Skip to main content

Glutamine and Quercetin as further drug candidates

Metabolic flux alignments showed first indications that the ammonia production might be reduced in some bromhidrosis cases.

This might leed to fast glutamine drainage in intestinal cells.

As a result glutamine supplementation might help ameliorating the low levels of glutamine and the reduced antioxidative effects in the cells.

A test with CACO2 test cells from the collegues from the alcoholism research showed promising results with glutamine as well.

A further supportive candidate is quercetine which is an antioxidant and a propsed inhibitor of the protein kinase which is related to the cAMP signaling. The cAMP signaling might be overactive in the same bromhidrosis cases.
The cAMP signaling is calcium and Vitamine D dependent, in the form that calcium and Vitamine D do further overactivate the cAMP signaling, which might have negative impacts.

Comments

  1. Fantastic Post! Lot of information is helpful in some or the other way. Keep updating quercetin supplements

    ReplyDelete

Post a Comment

Popular posts from this blog

Bromhidrosis TSH+: Diet protocol + nystatin, nigella sativa + h1 receptor antagonists + medicinal clay improves body odor condition

In our explorative case we were further able to improve the diet protocol as well as finding a new drug/supplement  composition. We are taking advantage of following over the counter drugs/supplements: - Nystatin - Nigella sativa (black cumin) capsules - H1 receptor antagonists (loratadin) - medicinal clay The diet protocol was taken from: https://drive.google.com/folderview?id=19hmatFJPil1svc9DRyuRn3S9rUF7yqH_ Dosages (daily) applied were like the following: nystatin: 6x pills (3x at morning, 3x at evening) nigella sativa: >10000mg (5x 400mg capsules before every meal, 5 meals per day) loratadin: 50mg - 100mg daily medicinal clay: 6x 6g (luvos healing earth)

The fecal body odor smell type

As stated in an earlier post, the most prominent reported smell type for TMAU2 patients was the fecal smell type. But not only TMAU positive patients reported such a type of smell, another body odor sufferer type do show the same fecal body odor pattern. Interestingly nearly all of those non TMAU patients report having Irritable Bowel Syndrom (IBS) as well. We took a closer look into the combined bacterial and human metabolism. The central chemical compound involved in the fecal smell seems to be indole. Indole is produced within the bacterial metabolism as a precursor of tryptophan. As major source the bacteria use glycolysis based on sugar, carbohydrates, ... To let the bacteria produce too much indole we found certain criteria: - Tryptophan absorption of the intestinal cells is lower than the serine and glycine absorption - Histidine malabsorption is present - Tyrosine malabsorption is present Why do TMAU2 patients now show a fecal smell, don't they have a choline and